Bring a large pot of salted water to a boil. Add the penne pasta and cook according to package instructions until al dente. Drain and set aside.

In a skillet over medium heat, add the sliced kielbasa. Cook until browned and heated through, about 5-7 minutes.

Reduce heat to low and add heavy cream to the skillet with kielbasa. Stir in cheddar and mozzarella cheese until melted and combined.

Add garlic powder, onion powder, Italian seasoning, salt, and pepper. Mix well.

Add the cooked pasta, spinach, and cherry tomatoes to the skillet. Toss to combine and heat through until spinach wilts.

Serve immediately, topped with additional cheese if desired.